Systems and methods are provided for routing voice communications through a mobile communication system having a self-contained infrastructure, such as a two-way radio communication system. The voice communications are transmitted as digitized voice packets over radio frequency links. The digitized voice packets contain one or more destination addresses in addition to other routing information. Routers receive the digitized voice packet and extract the routing information. The routing information is used in conjunction with a member router database to determine where to route the digitized voice packets.