A portable loudspeaker with a replaceable insertion base comprises: the loudspeaker; an insertion base; and a push mechanism. An insertion slot is formed on the loudspeaker for placing the insertion base. A first trench and a second trench are formed on the bottom of the insertion base in parallel with each other. A rib is formed between these two trenches. When the insertion base is coupled with the insertion slot, the hooks protrudent from the insertion slot are located to penetrate through the first trench and hook the rib, thereby inserting the terminal base of the insertion base into the socket of the loudspeaker for electrical connection. Besides, by using the push mechanism, the insertion base can be separated from the insertion slot rapidly. As a result, the insertion base can be replaced easily and it is also suitable for different digital music players.