The invention relates to compounds having formula (I), which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, a production method thereof and compositions containing same. According to the invention, Ar is a phenyl group substituted with one or more halogen groups; R.sub.1 is amino, hydroxyl or thiol, all of which may or may not be substituted with formula (II) or with aliphatic or cyclic groups; R.sub.2 is H or an alkyl, aryl, aralkyl or acyl group or formula (III); R.sub.3 is H or formula (IV); R.sub.4 and R.sub.6 are H or an aliphatic or cyclic group; R.sub.5 is H or formula (V); R.sub.7 is H or an aliphatic or cyclic group; Z is amino, hydroxyl or thiol, all of which may or may not be substituted with aliphatic or cyclic groups; W is a linkage or formula (VI); X is a linkage or formula (VII); Y is amino which may or may not be substituted with formula (VIII) or an alkyl, aryl, aralkyl or acyl group; m, q and s can vary between 1 and 9 and n and p can vary between 1 and 10 ##STR00001##