The system provides a Graphical User Interface which automatically updates labels associated with waveform information in multiple different windows within an individual image and in different images for use in a medical information telemetry system in synthesis and non-synthesis modes. A user interface display system for use in ECG signal management includes a display generator for generating at least one display image enabling assignment of two measured ECG chest lead signals to any two signals of the six ECG chest lead signals of a conventional 12 lead ECG signal set. A command processor automatically updates labels associated with the six ECG chest lead signals displayed in a display image to be compatible with the assignment of the two measured ECG chest lead signals in response to an assignment command made via the at least one display image.