There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH.sub.2. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

 
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> Compositions and methods related to soluble G-protein coupled receptors (sGPCRs)

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