Reagents that regulate human serine/threonine kinase and reagents which bind to human serine/threonine kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, diabetes, neurological disorders, cardiovascular disorders, musculo-skeletal disorders, inflammatory disorders, genitourological disorders, and respiratory disorders (e.g., asthma and COPD).