The present invention is directed to a 1,4-benzothiepine 1,1-dioxide
compound of formula I ##STR00001## in which the radicals have the
meanings defined herein, or a pharmaceutically acceptable salt or
physiologically functional derivative thereof, with at least one other
active ingredient, or a pharmaceutically acceptable salt or
physiologically functional derivative thereof. The invention is also
directed to the use of the combination product, pharmaceutical
composition comprising the combination product and method for preparing
the pharmaceutical composition.