The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I ##STR00001## in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.

 
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> Antisense modulation of PTP1B expression

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