The invention relates to a preserved, deantigenated tissue matrix of an animal or human hollow organ, e.g. of a blood vessel, of the ureter or urinary bladder, which matrix is autologous, allogenic or xenogenic with respect to a recipient and whose biomechanical properties are not or only slightly impaired by such preservation, which does not include any infectious particles from the donor and is excellently suited for coating with recipient endothelial, epithelial, fibroblast, or muscle cells in order to produce autologous grafts for said recipient. The invention is also directed to a method of producing said tissue matrix and to the use thereof, as well as to the autologous graft produced therefrom, and to the production and use thereof.