A technique is provided for partitioning an imaged volume into two or more sub-volumes. The technique identifies partition lines which separate the sub-volumes by generating a profile, such as a bone profile, which is then analyzed to determine the placement of the partition lines. In one embodiment, placement of the partition lines is determined automatically by applying one or more sets of hierarchical rules to the profile. After separation of the imaged volume into sub-volumes, each sub-volume may be differentially segmented such that segmentation is customized for the sub-volume. Likewise, after separation of the imaged volume into sub-volumes, the acquisition parameters for each sub-volume may be customized for subsequent acquisitions.