The invention relates to a rotary drive adapted for creating liquid flow in rotatable microfluidic discs. A rotary drive for spinning a disc shaped substrate having microfluidic structures formed therein for the flow control of microliter and/or nanoliter volumes of liquid by centrifugal force is suggested, comprising a motor with a spindle having an axis of rotation. A rotary member is connected for rotation with the spindle and driven for rotation relative to a stationary member, the rotary member being formed with a top plane having a centering guide for receiving the disc so as to force a symmetry axis of the disc into alignment with said axis of rotation. A vacuum source is connected with the stationary member and communicating with the rotary member or a part thereof rotating with the rotary member for applying sub-pressure to the disc when spinning the disc about its symmetry axis. Preferably, the rotary member is journalled for contact-free rotation relative to the stationary member.