An osmotic delivery system for controlled delivery of a beneficial agent
includes an implantable capsule containing a beneficial agent and an
osmotic engine that swells on contact with water, thereby causing the
release of the beneficial agent over time. The osmotic delivery system
has a membrane material that allows a controlled amount of fluid to enter
from an exterior of the capsule, while preventing the compositions within
the capsule from passing out of the capsule. The osmotic delivery system
is designed to meet at least the operating pressures of 1000 psi. The
membrane material is cast, calendered or extruded followed by machining
(i.e., die-cutting, stamping or otherwise cutting to shape) to provide a
uniform nonribbed membrane material. The capsule also includes a membrane
material-retaining means that is positioned at a fluid uptake end to
retain the membrane material within the capsule, even under periods of
high pressure.