The present invention relates to compounds of the Formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

 
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> N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

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