Systems, devices, and methods for facilitating muscular benefit using vascular occlusion are described. A device for providing vascular occlusion to a limb of an individual is described herein. The device is comprised of an inflatable band member, a pressure-inducing device, and a pressure control device. The device is adapted to be worn over an extended period of time either concurrent with exercise or not concurrent with exercise. Additionally, methods using the device are described wherein a limited pressure is applied to the limb and then maintained over an extended period of time. Methods are also described using a device wherein the individual applies the device to their limb, applies pressure to the limb by tightening and securing the device, and leaves the device in place over an extended period of time.