Compounds having the formula (I), ##STR00001## and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Z are as described in the specification.

 
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> Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors

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