A high molecular weight polysaccharide intracellular adhesin (SAE) antigen
having the general structure of poly-1,6,.beta.-2-amidoglucopyranoside,
which is variable substituted with N-acetyl and O-succinyl substituents
is described. Also, a method is given for isolating this antigen from
Staphylococcus aureus. The SAE can be used in a vaccine, either alone,
conjugated to an immunogenic protein, and/or with an immunogenic
adjuvant.