The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I: ##STR00001## that bind with high affifnity to CRF.sub.1 receptors, including human CRF.sub.1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.