The present invention provides a novel process for producing a calcium
phosphate cement or filler which hardens in a temperature dependent
fashion in association with an endothermic reaction. In the reaction a
limited amount of water is mixed with dry calcium phosphate precursors to
produce a hydrated precursor paste. Hardening of the paste occurs rapidly
at body temperature an is accompanied by the conversion of one or more of
the reactants to poorly crystalline apatitic calcium phosphate. The
hardened cements, fillers, growth matrices, orthopedic and delivery
devices of the invention are rapidly resorbable and stimulate hard tissue
growth and healing.