The present invention relates to a composition for liver protection and a preparing method of the same, the processes are as follows: grinding Artemisiae Capillaris and Gardeniae Fructus, mixing with pure water, and boiling the mixture. Then, adding the Rhei Rhizoma alcohol solution into the mixture for extraction to form the first solid phase and the first liquid phase, further concentrating the first liquid phase to form a concentrate, and adding alcohol into the concentrate for precipitation to form the second solid phase and second liquid phase, and separating the second solid phase and drying.