The invention is concerned with a novel polymorph of
[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine
hydrochloride. This polymorph exhibits superior properties compared to
the previously known forms of
[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine
hydrochloride. The
[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine
hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful
in the treatment of cancer. Also disclosed are methods of making and
using the novel polymorph, as well as pharmaceutical compositions
containing the novel polymorph.