The testing of tumor cells, including human tumors capable of metastases,
in assays employing fibronectin-depleted substrates is described. Ex vivo
induction of cells, including biopsied human cells, is performed with
invasion-inducing agents. Additionally, anti-cancer chemotherapeutics are
described. Specifically, chemotherapeutic agents which have
anti-metastatic and anti-growth properties are described including
non-peptide compositions of matter.