A system and method for application-transparent synchronization with a persistent data store. In one embodiment, the system may include a persistent data store configured to store a plurality of data items, such as a relational database, for example. The system may further include an application configured to modify a local data subset including a local copy of a given data item. The local data subset may be a disconnected rowset object, for example. Additionally, the system may include a first synchronization provider configured to synchronize the modified local data subset with the persistent data store, where synchronization of a given modified local copy with a corresponding data item occurs transparently to the application.