Method and apparatus for integrating a run-time parameterizable logic core with a static circuit design. A configuration bitstream is generated from a main circuit design that is specified in a hardware description language. The main circuit design includes a first sub-circuit design that specifies a selected subset of resources of the PLD needed by the RTP core and an interface between the RTP core and other parts of the main circuit design. Via execution of a run-time reconfiguration control program, the configuration data that correspond to the first sub-circuit design are replaced with configuration data that implement the RTP core. The run-time reconfiguration program then configures the PLD with the updated configuration bitstream.