Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3'-NHP(O)(S.sup.-)O-5' linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3'.fwdarw.P5' phosphoramidates and to exhibit a much higher acid stability.

 
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> Methods and systems for maintaining an encrypted video memory subsystem

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