Disclosed are methods for maintaining and/or improving the quality of at least one of epidermal, dermal or subcutaneous tissue in a subject. The subject may, in certain embodiments, be a post-menopausal human. The methods may comprise application of a soy formulation to the subject. Also disclosed are soy formulations, dietary supplements, food products, and pharmacological compositions that may be useful for maintaining and/or improving the quality of at least one of epidermal, dermal or subcutaneous tissue, including skin, hair, and nails.