The invention relates to a method of treatment for a mammal in need of
chemonucleolysis. The method comprising the administration of an
effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme
and an effective amount of a growth factor effective in promoting the
synthesis of a matrix component. The proteoglycan-degrading enzyme is
preferably chondroitinase. The growth factor is preferably osteogenic
protein. The proteoglycan-degrading enzyme and the growth factor are
preferably administered simultaneously.