The present invention is related to a compound of formula (I): A-B-E-D
(I), wherein: A is selected from the group consisting R.sup.a-L1-K-L2;
and (II) B is either present or absent, but if B is present then B is
(III), E is (IV), D is selected from the group comprising
--(CR.sup.1R.sup.m).sub.rC(O)H, --(CR.sup.1R.sup.m).sub.rC--N,
--CR.sup.1R.sup.m).sub.rNHNHC(O)NR.sup.5R.sup.6,
--(CR.sup.1R.sup.m).sub.rC(O)(CR.sup.nR.sup.o).sub.rc(O)OR.sup.7,
--(CR.sup.1R.sup.m).sub.rC(O)(Cr.sup.nR.sup.o).sub.rC(O)NR.sup.8R.sup.9,
--(CR.sup.1R.sup.m).sub.rCH(OH)(Cr.sub.nR.sup.o).sub.rC(O)U,
--(CR.sup.1R.sup.m).sub.rC(O)W--(CR.sup.1R.sup.m).sub.rC(O)CH.sub.2W,
--(CR.sup.1R.sup.m).sub.rC(O)haloalkyl, and
--(CR.sup.1R.sup.m).sub.rC(O)(CR.sup.nR.sup.o).sub.r--CHN.sub.2, and the
use of said compounds as an inhibitor to rotamases.
