The present invention provides a process for the preparation of
6-O-methylerythromycin A Form II comprising treating
6-O-methylerythromycin A with organic acid selected form trifluoroacetic
acid, para-toluene sulphonic acid, oxalic acid or acetic acid and
converting it into an organic salt of 6-O-methylerythromycin A, which can
be neutralized by base to give 6-O-methylerythromycin A Form II.