In a human or animal organ or other region of interest, specific objects, such as liver metastases and brain lesions, serve as indicators, or biomarkers, of disease. In a three-dimensional image of the organ, the biomarkers are identified and quantified both before and after a surgical implant is implanted, and their reaction to the surgical implant is observed. Statistical segmentation techniques are used to identify the biomarker in a first image and to carry the identification over to the remaining images.