A method and a device for operating an internal combustion engine having a plurality of cylinders are described, each cylinder having at least one intake valve and one exhaust valve having fully variable valve control, a fuel feed to at least one first cylinder of the plurality of cylinders being deactivated, a first quantity of fresh air being drawn in by opening the at least one intake valve of the at least one first cylinder in a first downward movement of the piston of the at least one first cylinder, and a second quantity of fresh air being ejected by opening the at least one exhaust valve with a first upward movement of the piston of the at least one first cylinder.