Novel compounds are provided having formula (I) ##STR00001## whereR.sub.1, R.sub.2, R.sub.3, R.sub.4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

 
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< Purine derivatives

< Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1R, cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents

> Histamine-3 receptor modulators

> HIV integrase inhibitors
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