A theory has been presented that provides a simplified explanation of a
cohesive mechanism of embryological development, hemostasis, coagulation,
wound repair and tissue maintenance that operates continuously in the
animal body to oppose the effects of stress. The theory endeavors to fit
all known facts, and is based on the hypothesis that coagulation Factors
VII and VIII are respectively local and systemic stress agents that
regulate thrombin activity and synergize each other's effects. Stress
Theory may explain the etiologies of several hitherto mysterious disease
syndromes, and the stress mechanism lo and may play a more pervasive role
in disease than is generally appreciated. The theory offers fresh avenues
for research and clinical strategy.