A self-calibrating transmitter includes an up-conversion mixing module, summing module, calibration determination module, and a calibration execution module. The up-conversion mixing module is operably coupled to mix an I component of a base-band signal with an I component of a local oscillation to produce a mixed I signal and is also operably coupled to mix a Q component of the base-band signal with a Q component of the local oscillation to produce a mixed Q signal. The summing module sums the mixed I signal with the mixed Q signal to produce a modulated radio frequency (RF) signal. The calibration determination module is operably coupled to produce a calibration signal, which it generates by interpreting the local oscillation and the modulated RF signal. The calibration execution module is operably coupled to calibrate the DC level of the I and/or Q component of the base-band signal, and/or the gain of the I and/or Q component of the base-band signal based on the calibration signal.