The present invention relates to Tumor Necrosis Factor Related Ligand (TRELL), a novel member of the tumor necrosis factor family (TNF), modified TRELL, and pharmaceutical compositions comprising them.

 
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< TNF-.alpha. binding molecules

< Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-.alpha. converting enzyme

> Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof

> Methods for treating neuropathological states and neurogenic inflammatory states and methods for identifying compounds useful therein

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