Methods and apparatuses for treating fluids to inactivate microorganisms
which may be present therein, said fluid containing one or more
components selected from the group consisting of protein, blood and blood
constituents are provided. The methods comprise adjusting the percentage
of plasma in said fluid to a desired value; mixing an
inactivation-effective, substantially non-toxic amount of an endogenous
photosensitizer or endogenously-based derivative photosensitizer to said
fluid; exposing said fluid to photoradiation of sufficient wavelength and
energy to activate the photosensitizer, whereby said microorganisms are
inactivated.