Disclosed are methods and compositions for early diagnosis, monitoring and treatment of cartilage degenerative conditions, including forms of arthritis. In particular, the invention relates to a protein, termed "adlican," that is differentially transcribed and expressed in human subjects suffering from arthritis, such as osteoarthritis (OA) and rheumatoid arthritis (RA) compared with non-arthritis sufferers, antibodies which recognize this protein, and methods for diagnosing arthritis.

 
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< Hybrid molecules and their use for optically detecting changes in cellular microenvironments

< AGE-1 polypeptides and related molecules and methods

> Replication protein a binding transcriptional factor (RBT1) and uses thereof

> Poly ADP-ribose polymerase gene and it uses

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