Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR00001## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

 
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< Immune modulation device for use in animals

< Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins

> 5-substituted isoquinoline derivatives

> RD114-based retroviral packaging cell line and related compositions and methods

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