This invention concerns compounds of formula a N-oxide, a
pharmaceutically acceptable addition salt, a quaternary amine and a
stereochemically isomeric form thereof, wherein ring A represents phenyl,
pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R.sup.1 represents
hydrogen; aryl; formyl; C.sub.1-6alkylcarbonyl; C.sub.1-6alkyl;
C.sub.1-6alkyloxycarbonyl; C.sub.1-6alkyl substituted with formyl,
C.sub.1-6alkylcarbonyl, C.sub.1-6alkyloxycarbonyl,
C.sub.1-6alkylcarbonyloxy; or optionally substituted
C.sub.1-6alkyloxyC.sub.1-6alkylcarbonyl; X.sub.1 represents a direct
bond; --(CH.sub.2).sub.n3-- or --(CH.sub.2).sub.n4--X.sub.1a--X.sub.1b--;
R.sup.2 represents optionally substituted C.sub.3-7cycloalkyl; phenyl; a
4, 5, 6- or 7-membered monocyclic heterocycle containing at least one
hetetoatom selected from O, S or N; benzoxazolyl or a radical of formula
X.sub.2 represents a direct bond; --NR.sup.1--;
--NR.sup.1--(CH.sub.2).sub.n3--; --O--; --O--(CH.sub.2).sub.n3--;
--C(.dbd.O)--; --C(.dbd.O)--(CH.sub.2).sub.n3--;
--C(.dbd.O)--NR.sup.5--(CH.sub.2).sub.n3--; --C(.dbd.S)--; --S--;
--S(.dbd.O).sub.n1--; --(CH.sub.2).sub.n3--;
--(CH.sub.2).sub.n4--X.sub.1a--X.sub.1b--;
--X.sub.1a--X.sub.1b--(CH.sub.2).sub.n4--;
--S(.dbd.O).sub.n1--NR.sup.5--(CH.sub.2).sub.n3--NR.sup.5-- or
--S(.dbd.O).sub.n1--NR.sup.5--(CH.sub.2).sub.n3--; R.sup.3 represents an
optionally substituted 5- or 6-membered monocyclic heterocycle containing
at least one heteroatom selected from O, S or N, or a 9- or 10-membered
bicyclic heterocycle containing at least one heteroatom selected from O,
S or N; R.sup.4 represents hydrogen; halo; hydroxy; optionally
substituted C.sub.1-4alkyl; optionally substituted C.sub.2-4alkenyl or
C.sub.2-4alkynyl; polyhaloC.sub.1-3alkyl; optionally substituted
C.sub.1-4alkyloxy; polyhaloC.sub.1-3alkyloxy; C.sub.1-4alkylthio;
polyhaloC.sub.1-3alkylthio; C.sub.1-4alkyloxycarbonyl;
C.sub.1-4alkylcarbonyloxy; C.sub.1-4alkylcarbonyl;
polyhaloC.sub.1-4alkylcarbonyl; nitro; cyano; carboxyl; NR.sup.9R.sup.10;
C(.dbd.O)NR.sup.9R.sup.10; --NR.sup.5--C(.dbd.O)--NR.sup.9R.sup.10;
--NR.sup.5--C(.dbd.O)--R.sup.11; --S(.dbd.O).sub.n1--R.sup.11;
--NR.sup.5--S(.dbd.O).sub.n1--R.sup.11; --S--CN; --NR.sup.5--CN; their
use, pharmaceutical compositions comprising them and processes for their
preparation.
