Encryption synchronization (e-sync) is maintained between a transmitter (104) and one or more receivers (102) in a multi-modulation TDM system (100) where information is communicated in slots (402) comprising a slot header (404) and one or more data blocks (406), and wherein the data blocks are eligible to be encoded at different modulation rates thereby creating a likelihood of different numbers of blocks in different slots. The receiver and transmitter employ respective encryption elements (200, 300) comprising e-sync shifter elements (202, 302) and encryption algorithm blocks (204, 304). The e-sync shifter element provides an e-sync signal defining an encryption state vector to the encryption algorithm block and is operable to advance the encryption state vector (in the case of the receiver) according to a number of received bits plus a variable number of bits. The variable number depends on the number of bits within a block, the maximum number of blocks that could be within a slot and the actual number of blocks within the slot.