The present invention is directed to a three-dimensional printing system and method, and an article made therefrom. The method of the present invention includes building cross-sectional portions of a three dimensional article, and assembling the individual cross-sectional areas in a layer-wise fashion to form a final article. The individual cross-sectional areas are built using an ink-jet printhead to deliver an aqueous fluid to a particle material that includes a first particulate material, a second particulate material, and a third particulate material, wherein the first and second particulate materials react in the presence of the fluid in a period of time, and the third particulate material reacts in the presence of the fluid to form a solid in a longer period of time.