A tissue treatment device suitable for use on an extremity or a portion of an extremity, such as a hand or foot, includes a cover formed as a bag, sac, or pouch, and a flexible, absorbent support member. Defined sections of the support member may be removed from the support member to form an opening therein. The support member is for being positioned within the cover to support a portion of the cover off of, and out of contact with, tissue to be treated. The cover has an open end with attachment means disposed thereon for attachment to the extremity or extremity portion that is received in the cover. The support member may be impregnated with a medicament. The removable sections allow formation of an opening that may be customized or adapted to the area of tissue that is to receive treatment. This permits the tissue treatment device to be adapted for use with treatment areas that vary in size, shape, contour, and composition.