Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a
cell nucleus. PARP-1 is a target for the development of radio and chemo
sensitizing agents in cancer treatment as well as providing protection
from stroke. An SH3 domain and an SH3 ligand domain have now been
discovered on the PARP-1 protein. These domains are involved in PARP-1
activation. This discovery makes possible the use of bioinformatics tools
for the design of new drugs and strategies for drug target selection,
specifically targeting the PARP-1 enzyme.