It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.

 
Web www.patentalert.com

< NUCLEIC ACID SEQUENCES ENCODING MELANOMA ASSOCIATED ANTIGEN MOLECULES, AMINOTRANSFERASE MOLECULES, ATPASE MOLECULES, ACYLTRANSFERASE MOLECULES, PYRIDOXAL-PHOSPHATE DEPENDENT ENZYME MOLECULES AND USES THEREFOR

< Method of regulating glucose metabolism, and reagents related thereto

> Temperature mapping balloon

> Human tumor necrosis factor TR21 and methods based thereon

~ 00275