A method of preparing and operating a subsea well (23), comprising the steps of: locating a drill-through subsea tree (24) on a subsea wellhead; sealingly connecting a high pressure drilling riser (22) between the tree and a drilling platform at the sea surface; mounting a blow out preventer (16) at the top of the riser (22); drilling the well through the drilling riser and the subsea tree; and establishing a production connection between the tree (24) and a production collection facility at the sea surface through a production riser (52) which is separate from the drilling riser (22).