This invention provides isolated nucleic acids encoding chimeric G
proteins, vectors comprising nucleic acids encoding chimeric G proteins,
cells comprising such vectors, processes of determining agonists and
antagonists of mammalian G protein-coupled receptors utilizing chimeric G
proteins, processes of determining compounds which bind to mammalian G
protein-coupled receptors utilizing chimeric G proteins, processes for
making a composition of matter which specifically binds to a mammalian G
protein-coupled receptor utilizing chimeric G proteins, processes for
preparing a composition which comprises admixing a carrier and a
pharmaceutically effective amount of a chemical compound identified by a
process of the invention utilizing chimeric G proteins, processes of
identifying a ligand for a mammalian G protein-coupled receptor utilizing
chimeric G proteins, and processes of screening a plurality of
independent clones to identify and isolate a clone encoding a mammalian G
protein-coupled receptor utilizing chimeric G proteins.