The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (I.sub.a), wherein R.sub.a represents H or lower alkyl, and R.sub.1 represents H or perfluoro lower alkyl, R.sub.2 represents H, halogen, C.sub.2 C.sub.7alkyl, C.sub.2 C.sub.7alkenyl or lower aklynyl; or Ar is represented by the subformula (I.sub.b) and R.sub.1 represents perfluoro lower alkyl, and R.sub.2 represents bromo, iodo, C.sub.2 C.sub.7alkyl, C.sub.2 C.sub.7alkenyl or lower alkynyl, or R.sub.1 represents H, and R.sub.2 represents fluoro, bromo, iodo, ethyl, C.sub.5 C.sub.7alkyl, C.sub.2 C.sub.7alkenyl or lower alkynyl; to N-oxides and tautomers thereof, and to salts of such anthranilic acid amides, its N-oxides and tautomers; to processes for their preparation; to their application in the treatment of the human or animal body, to the use thereof--alone or in combination with one or more other pharmaceutically active compounds--for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age-related macular degeneration; to a method for the treatment of such diseases in animals; and to the use of such a compound--alone or in combination with one or more other pharmaceutically active compounds--for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration.