Ankle prosthesis apparatuses, systems and methods are provided as disclosed herein. Additionally, systems and methods for bone resection and implantation of prosthetics are provided, including surgical techniques and related instrumentation. An ankle prosthesis apparatus can include a talar component having a lower surface with a bone fixation portion for fixation to a talus bone and an upper surface designed for articulation with a bearing component. The bearing component can have a lower surface for articulation with the talar component and an upper surface for articulation with a tibial component. The tibial component can have a lower surface for articulation with the bearing component and an upper surface with a bone fixation portion for fixation to a tibia bone and/or a fibula bone. The bearing component can have a protrusion on its upper surface adapted for engagement with a recess on the tibial component to allow desired rotational and translational movement. Methods and systems can be used to prepare a bone surface for implantation of a prosthesis including determining a location for a curved cut line on the bone surface and drilling a series of holes tangent to the curved cut line to create a curved bone resection surface. Methods and systems can be used for the implantation of an ankle joint prosthesis including the use of an alignment guide, tibia and talus drill guides, tibia and talus saw guides, and tibia and talus broach guides, all components of which can be placed on and removed from a plurality of alignment anchor pins throughout the implantation procedure. A method for medially to laterally implanting an ankle joint prosthesis can include exposing tibia and talus bones from the medial side, resection of the tibia and talus bones, broaching the tibia and talus bones, and positioning and affixing the ankle joint prosthesis components.