Nucleic acid, including DNA, for immunization to generate a protective
immune response in a host, including humans, to a major outer membrane
protein of a strain of Chlamydia, preferably contains a nucleotide
sequence encoding a fragment that generates antibodies that specifically
react with MOMP and a promoter sequence operatively coupled to the first
nucleotide sequence for expression of the MOMP fragment in the host. The
non-replicating vector may be formulated with a
pharmaceutically-acceptable carrier for in vivo administration to the
host.