The invention provides an article of manufacture comprising a
substantially non-immunogenic injectable collagen for implantation into
humans. The invention further provides methods for preparing injectable
collagen material by removing collagen-containing material from a
non-human animal; washing in saline and alcohol; subjecting material to
cellular disruption treatment; and digesting the material with a
proteoglycan-depleting factor and/or glycosidase and optionally following
with a capping treatment. The invention also provides an article of
manufacture produced by the method. The injectable collagen material of
the invention are substantially non-immunogenic and have substantially
the same mechanical properties as a corresponding native soft tissue.