This disclosure is directed to techniques for selection of wireless network interfaces for data communication within an access terminal. The techniques may rely on a set of interface selection rules to identify network interfaces that are eligible to serve a particular communication application or the type of traffic forwarded on behalf of another device. In addition, each network interface may be assigned a priority. Upon identifying eligible interfaces, e.g., interfaces that satisfy all of the interface selection rules, the techniques may involve selection of the eligible interface having the highest priority. The assigned priority may be dynamically adjusted based on the connection state of the interfaces, prioritization according to changes in system latency, interface cost, and the like.