The invention discloses a method of locating and measuring a mobile station, which relates with the radio locating technique in mobile communication field. Comparing with the conventional radio locating technique, the method improves the first path determination method of a neighbor base station downlink signal as follows: with geometrical relationship such as the distance between a MS to the reference base station and the distance between a neighbor base station to the reference base station, an effective range of the downlink signal first path of the neighbor base station can be calculated; the effective range is an effective search window that is shorter than the original large search window, and the first path determination of the neighbor base station downlink signal is made within the effective search window. The invention raises the first path determination accuracy of a neighbor base station downlink signal, so the mobile station locating accuracy is raised too.